Kaulich PT, Cassidy L, Bartel J, Schmitz RA, Tholey A
Multi-protease approach for the improved identification and molecular characterization of small proteins and short open reading frame-encoded peptides
Journal Proteme Research. accepted.

Fuchsa ACD, Ammelburga M, Martin J, Schmitz RA, Hartmanna MD, Lupas AN
Archaeal Connectase is a specific and efficient protein ligase related to proteasome β subunits
PNAS. Vol. 118 No. 11 e2017871118, doi: 10.1073/pnas.2017871118

Gutt M, Jordan B, Weidenbach K, Gudzuhn M, Kiessling C, Cassidy L, Helbig A, Tholey A, Pyper DJ, Kubatova N, Schwalbe H, Schmitz RA
High complexity of Glutamine synthetase regulation in Methanosarcina mazei: Small protein 26 interacts and enhances glutamine synthetase activity
FEBS J. doi: 10.1111/febs.15799. Online ahead of print.

Cassidy L, Helbig AO, Kaulich PT, Weidenbach K, Schmitz RA, Tholey A
Multidimensional separation schemes enhance the identification and molecular characterization of low molecular weight proteomes and short open reading frame-encoded peptides in top-down proteomics
J Proteomics. 230:103988. doi: 10.1016/j.jprot.2020.103988.


Stevens KM, Swadling JB, Hocher A, Bang C, Gribaldo S, Schmitz RA, Warnecke T
Histone variants in archaea and the evolution of combinatorial chromatin complexity
PNAS . 117(52):33384-33395. doi: 10.1073/pnas.2007056117. Epub 2020 Dec 7.

Weiland-Bräuer N, Pinnow N, Langfeldt D, Roik A, Güllert S, Chibani CM, Reusch TBH, Schmitz RA
The native microbiome is crucial for offspring generation and fitness of Aurelia aurita
mBio. 11(6):e02336-20. doi: 10.1128/mBio.02336-20

Chibani CM, Roth O, Liesegang H, Wendling CC
Genomic variation among closely related Vibrio alginolyticus strains is located on mobile genetic elements
BMC Genomics. 21(1):354. doi: 10.1186/s12864-020-6735-5.

Blow F, Bueno E, Clark N, Tong Zhu D, Ho Chung S, Güllert S, Schmitz RA, Douglas AE
B-vitamin nutrition in the pea aphid-Buchnera symbiosis
Journal of Insect Physiology. 126:104092. doi: 10.1016/j.jinsphys.2020.104092. Epub 2020 Aug 4.

Ulbricht A, Nickel L, Weidenbach K, Vargas Gebauer H, Kießling C, Förstner KU, Schmitz RA
The CARF Protein MM_0565 Affects Transcription of the Casposon-Encoded cas1-solo Gene in Methanosarcina mazei Gö1
Biomolecules. 10(8):E1161. doi: 10.3390/biom10081161.

Borrel G, Brugère JF, Gribaldo S, Schmitz RA, Moissl-Eichinger C
The host-associated archaeome
Nature Reviews Microbiology. . 18(11):622-636. doi: 10.1038/s41579-020-0407-y. Epub 2020 Jul 20.

Kaulich PT, Cassidy L, Weidenbach K, Schmitz RA, Tholey A
Complementarity of Different SDS‐PAGE Gel Staining Methods for the Identification of Short Open Reading Frame‐encoded Peptides
Proteomics., 20(19-20):e2000084. doi: 10.1002/pmic.202000084. Epub 2020 Aug 19.

Mensch B, Neulinger SC, Künzel S, Wahl M, Schmitz RA
Warming, but Not Acidification, Restructures Epibacterial Communities of the Baltic Macroalga Fucus vesiculosus with Seasonal Variability
Frontiers of Microbiology. 11:1471. doi: 10.3389/fmicb.2020.01471. eCollection 2020.

Weiland-Bräuer N, Prasse D, Brauer A, Jaspers C, Reusch TBH, Schmitz RA
Cultivable microbiota associated with Aurelia aurita and Mnemiopsis leidyi
MicrobiologyOpen. 9(9):e1094. doi: 10.1002/mbo3.1094. Epub 2020 Jul 11.

Jaspers C, Weiland-Bräuer N, Rühlemann MC, Baines JF, Schmitz RA, Reusch TB
Differences in the microbiota of native and non-indigenous gelatinous zooplankton organisms in a low saline environment
Science of The Total Environment. Volume 734:139471. doi: 10.1016/j.scitotenv.2020.139471. Epub 2020 May 16.

Louropoulou E, Gledhill M, Achterberg EP, Browning TJ, Honey DJ, Schmitz RA, Tagliabue A
Heme b distributions through the Atlantic Ocean; evidence for "anemic" phytoplankton populations.
Scientific Reports. 10(1):4551. doi: 10.1038/s41598-020-61425-0.

Turner B, Burkhart BW, Weidenbach K, Ross R, Limbach PA, Schmitz RA, de Crécy-Lagard V, Stedman KM, Santangelo TJ, Iwata-Reuyl D
Archaeosine modification of archaeal tRNA – a role in structural stabilization.
J. Bact. 202(8). pii: e00748-19. doi: 10.1128/JB.00748-19.


Kubatova N, Pyper DJ, Jonker HRA, Saxena K, Remmel L, Richter C, Brantl S, Evguenieva-Hackenberg E, Hess W, Klug G, Marchfelder A, Soppa J, Streit W, Mayzel M, Orekhov VY, Fuxreiter M, Schmitz RA, Schwalbe H
Rapid biophysical characterization and NMR structural analysis of small proteins from bacteria and archaea.
Chembiochem. 21(8):1178-1187. doi: 10.1002/cbic.201900677.

Callbeck CM, Pelzer C, Lavik G, Ferdelman TG, Graf JS, Vekeman B, Schunck H, Littmann S, Fuchs BM, Hach PF, Kalvelage T, Schmitz RA, Kuypers MMM
Arcobacter peruensis sp. nov., a Chemolithoheterotroph Isolated from Sulfide- and Organic-Rich Coastal Waters off Peru.
Appl Environ Microbiol. 85(24). pii: e01344-19. doi: 10.1128/AEM.01344-19.

Rausch P, Rühlemann M, Hermes B, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Henschel Humeida U, Heinsen F-A; Höppner M, Jahn M, Jaspers C, Kissoyan CA; Langfeldt D; Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF
Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms.
Microbiome. 7(1):133. doi: 10.1186/s40168-019-0743-1.

Fischer MA, Ulbricht A, Neulinger SC, Refai S, Waßmann K, Künzel S, Schmitz RA
Immediate Effects of Ammonia Shock on Transcription and Composition of a Biogas Reactor Microbiome.
Front. Microbiol. 10:2064. doi: 10.3389/fmicb.2019.02064. eCollection 2019.

Louropoulou E, Gledhill M, Browning TJ, Desai DK, Menzel Barraqueta J-L, Tonnard M, Sarthou G, Planquette H, Bowie AR, Schmitz RA, LaRoche J, Achterberg EP
Regulation of the phytoplankton heme b iron pool during the North Atlantic spring bloom.
Frontiers in Microbiology,

Schwarz TS, Wäber NB, Feyh R, Weidenbach K, Schmitz RA, Marchfelder A, Hartmann RK
Homologs of aquifex aeolicus protein-only RNase P are not the major RNase P activities in the archaea haloferax volcanii and methanosarcina mazei.
IUBMB Life. 71(8):1109-1116. doi: 10.1002/iub.2122. Epub 2019 Jul 8.

Sieber M, Pita L, Weiland-Bräuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U, Schulenburg H, Bosch TCG, Traulsen A
Neutrality in the Metaorganism.
PLOS Biology, 17(6):e3000298. doi: 10.1371/journal.pbio.3000298. .

Jaspers C, Weiland-Bräuer N, Fischer M, Künzel S, Schmitz RA, Reusch TBH
Microbiota differences in native and invasive Mnemiopsis leidyi sub-populations.

Prasse D, Weiland-Bräuer N, Jaspers C, Reusch TBH, Schmitz RA
Evaluating quorum quenching potential of bacteria associated to Aurelia aurita and Mnemiopsis leidyi.

Weiland-Bräuer N, Malek I, Schmitz RA
Metagenomic quorum quenching enzymes affect biofilm formation of Candida albicans and Staphylococcus epidermidis.
PLoS One 14(1):e0211366. doi: 10.1371/journal.pone.0211366.

Weiland-Bräuer N, Pinnow N, Fischer MA, Schmitz RA
Potential role of host-derived quorum quenching in modulating bacterial colonization in the moon jellyfish Aurelia aurita.
Scientific Reports, 9(1), 34

Wolf S, Fischer MA, Kupczok A, Reetz J, Kern T, Schmitz RA and Rother M
Characterization of the lytic archaeal virus Drs3 infecting Methanobacterium formicicum.
Archives of Virology 164(3):667-674. doi: 10.1007/s00705-018-04120-w. Epub 2018 Dec 6.


Esser D, Lange J, Marinos G, Sieber M, Best L, Prasse D, Bathia J, Rühlemann MC, Boersch K, Jaspers C, Sommer F
Functions of the Microbiota for the Physiology of Animal Metaorganisms.
J Innate Immun 19:1-12. doi: 10.1159/000495115.

Buddeweg A, Daume M, Randau L, Schmitz RA
Noncoding RNAs in Archaea: Genome-Wide Identification and Functional Classification.
Methods Enzymol 612:413-442. doi: 10.1016/bs.mie.2018.08.003.

Buey RM, Schmitz-Streit RA , Buchanan BB, Balsera M
Crystal structure of the apo-form of NADPH-thioredoxin reductase from a methane-producing archaeon.
Antioxidants (Basel) 7(11). pii: E166. doi: 10.3390/antiox7110166.

Bang C, Schmitz RA
Archaea – forgotten players in the microbiome.
Emerging Topics in Life Sciences, Biochemical Society/Portland Press accepted

Callbeck CM, Lavik G, Ferdelman TG, Fuchs B, Gruber-Vodicka HR, Hach PF, Littmann S, Schoffelen NJ, Kavelage T, Thomsen S, Schunck H, Löscher C, Schmitz RA, Kuypers MMM
Oxygen minimum zone cryptic sulfur cycling sustained by offshore transport of key sulfur oxidizing bacteria.
Nature communication 9(1):1729. doi: 10.1038/s41467-018-04041-x

Fischer MA, Güllert S, Künzel S, Deppenmeier U, Streit WR, Schmitz RA
Long-term investigation of microbial community composition and transcription patterns in a biogas plant undergoing ammonia crisis.
Microbial Biotechnology 112(2):305-323. doi: 10.1111/1751-7915.13313.

Nickel L, Ulbricht A, Alkhnbashi OS, Förstner KU, Cassidy L, Weidenbach K, Backofen R, Schmitz RA
Cross-cleavage activity of Cas6b in crRNA processing of two different CRISPR-Cas systems in Methanosarcina mazei Gö1.
RNA Biology 16(4):492-503. doi: 10.1080/15476286.2018.1514234.

Prasse D, Schmitz RA
Small RNAs involved in regulation of nitrogen metabolism
Microbiology Spectrum 6(4): RWR – 0018-2018. doi:10.1128/micorbiolspec.RWR-0018-2018.

Bang C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Pita L, Pogoreutz C, Rädecker N, Saad MM, Schmitz RA, Schulenburg H, Voolstra CR, Weiland-Bräuer N, Ziegler M, Bosch TCG
Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?
Zoology (Jena). 127:1-19. doi: 10.1016/j.zool.2018.02.004. Epub 2018 Feb 15. Review.

Callbeck CM, Lavik G, Ferdelman TG, Fuchs B, Gruber-Vodicka HR, Hach PF, Littmann S, Schoffelen NJ, Kavelage T, Thomsen S, Schunck H, Löscher C, Schmitz RA, Kuypers MMM
Oxygen minimum zone ‘cryptic sulfur cycling’ sustained by offshore transport of key sulfur oxidizing bacteria
Nature communication. 9(1):1729. doi: 10.1038/s41467-018-04041-x.

Buddeweg A, Sharma K, Urlaub H, Schmitz RA
sRNA41 affects ribosome binding sites within polycistronic mRNAs in Methanosarcina mazei Gö1.
Molecular Microbiology. 107(5):595-609. doi: 10.1111/mmi.13900. Epub 2018 Jan 18.

Martínez-Pérez C, Mohr W, Schwedt A, Dürschlag J, Callbeck CM, Schunck H, Dekaezemacker J, Buckner CRT, Lavik G, Fuchs BM, Kuypers MMM
Metabolic versatility of a novel N2-fixing Alphaproteobacterium isolated from a marine oxygen minimum zone.
Environ Microbiol. 20(2):755-768. doi: 10.1111/1462-2920.14008. Epub 2018 Jan 3.


Vierbuchen T, Bang C, Rosigkeit H, Schmitz RA,Heine H
The Human-Associated Archaeon Methanosphaera Stadtmanae is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation.
Front. Immunol. 8:1535. doi: 10.3389/fimmu.2017.01535. eCollection 2017.

Koskinen K, Pausan MR, Perras AK, Beck M, Bang C, Mora M, Schilhabel A, Schmitz RA, Christine Moissl-Eichinger C.
First insights into the diverse human archaeome: specific archaea detection in the gastrointestinal tract, lung, nose and on skin.
mBio. 8(6). pii: e00824-17. doi: 10.1128/mBio.00824-17.

Bang C, T. Vierbuchen T, Gutsmann T, Heine T, Schmitz RA.
Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides.
PLOS ONE. 12(10):e0185919. doi: 10.1371/journal.pone.0185919. eCollection 2017.

Weidenbach K, Nickel L, Neve H, Alkhnbashi OS, Künzel S, Kupczok A, Bauersachs T, Cassidy L, Tholey A, Backofen R, Schmitz RA.
MetSV, a novel archaeal lytic virus targeting Methanosarcina strains.
J Virol. 91(22). pii: e00955-17. doi: 10.1128/JVI.00955-17.

Moissl-Eichinger C, Pausan M, Taffner J, Berg G, Bang C, Schmitz RA.
Archaea Are Interactive Components of Complex Microbiomes.
Trends Microbiol. S0966-842X(17)30174-9. doi: 10.1016/j.tim.2017.07.004. [Epub ahead of print] Review.

Weiland-Bräuer N, Schmitz RA
Quenching bacterial communication: Innovative strategies for biofilm inhibition.
In Microbiology Science Book series ‘Antimicrobial esearch: Novel bioknowledge and educational programs’ A. Méndez-Vilas (ed.), p. 331-343, Formatex Research Center. ISBN (13): 978-84-947512-0-2
No abstract available.

Weiland-Bräuer N, Fischer MA, Schramm KW, Schmitz RA
Polychlorinated biphenyl (PCB)-degrading potential of microbes present in a cryoconite of Jamtalferner glacier.
Front Microbiol. 8:1105. doi: 10.3389/fmicb.2017.01105. eCollection 2017.

Prasse D, Förstner KU, Jäger D, Rolf Backofen, Schmitz RA
sRNA154 a newly identified regulator of nitrogen fixation in Methanosarcina mazei strain Gö1.
RNA Biol. 14(11):1544-1558. doi: 10.1080/15476286.2017.1306170.

Weiland-Bräuer N, Langfeldt D, Schmitz RA
Construction and Screening of Marine Metagenomic Large Insert Libraries.
Methods Mol Biol. 1539:23-42.


Cassidy L, Prasse D, Linke D, Schmitz RA, Tholey A
Combination of Bottom-up 2D-LC-MS and Semi-top-down GelFree-LC-MS Enhances Coverage of Proteome and Low Molecular Weight Short Open Reading Frame Encoded Peptides of the Archaeon Methanosarcina mazei.
J Proteome Res. 15(10): 3773-3783.

Martínez-Pérez C, Mohr W, Löscher CR, Dekaezemacker J, Littmann S, Yilmaz P, Lehnen N, Fuchs BM, Lavik G, Schmitz RA, LaRoche J, Kuypers MM.
The small unicellular diazotrophic symbiont, UCYN-A, is a key player in the marine nitrogen cycle.
Nat Microbiol. 1(11):16163. doi: 10.1038/nmicrobiol.2016.163.

Dar D, Prasse D, Schmitz RA, Sorek R
Widespread formation of alternative 3′ UTR isoforms via transcription termination in archaea
Nat Microbiol. 1(10):16143. doi: 10.1038/nmicrobiol.2016.143.

Fischer MA, Güllert S, Neulinger SC, Streit WR, Schmitz RA
Evaluation of 16S rRNA gene primer pairs for monitoring microbial community structures showed high reproducibility within and low comparability between datasets generated with multiple archaeal and bacterial primer pairs
Front Microbiol. 7: 1297. doi:  10.3389/fmicb.2016.01297

Malek I, Schaber CF, Heinlein T, Schneider JJ, Gorb SN, Schmitz RA
Vertically aligned multi Walled Carbon Nanotubes prevent Biofilm Formation of Medically Relevant Bacteria
Journal of Materials Chemistry B. 4: 5228-5235

Weiland-Bräuer N, Kisch M, Pinnow N, Liese A, Schmitz RA
Highly effective inhibition of biofilm formation by the first metagenome-derived AI-2 quenching enzyme
Front Microbiol. 7:1098. doi: 10.3389/fmicb.2016.01098

Güllert S, Fischer MA, Turaev D, Noebauer B, Ilmberger N, Wemheuer B, Alawi M, Rattei T, Daniel R, Schmitz RA, Grundhoff A, Streit WR
Deep metagenome and metatranscriptome analyses of microbial communities affiliated with an industrial biogas fermenter, a cow rumen, and elephant feces reveal major differences in carbohydrate hydrolysis strategies
Biotechnology for Biofuels. 9:121 doi: 10.1186/s13068-016-0534-x

Mensch B, Neulinger SC, Graiff A, Pansch A, Künzel S, Fischer MA, Schmitz RA
Restructuring of epibacterial communities on Fucus vesiculosus forma mytili in response to elevated pCO2 and increased temperature levels.
Front Microbiol. 7:434. doi: 10.3389/fmicb.2016.00434

Arévalo-Martínez DL, Kock A, Löscher CR, Schmitz RA, Stramma L, Bange HW
Influence of mesoscale eddies on the distribution of nitrous oxide in the eastern tropical South Pacific.
Biogeosciences. 13, 1105-1118, doi:10.5194/bg-13-1105-2016

Kern T, Fischer MA, Deppenmeier U, Schmitz RA, Rother M
Methanosarcina flavescens sp. nov., a methanogenic archaeon isolated from a full-scale anaerobic digester.
Int J Syst Evol Microbiol. 66(3):1533-1538. doi: 10.1099/ijsem.0.000894. Epub 2016 Jan 12.


Meyer J, Löscher CR, Neulinger SC, Reichel AF, Loginova A, Borchard C, Schmitz RA, Hauss H, Kiko R, Riebesell U
Changing nutrient stoichiometry affects phytoplankton production, DOP build up and dinitrogen fixation – a mesocosm experiment in the eastern tropical North Atlantic.
Biogeosciences. 13, 781-794

Löscher CR, Fischer MA, Neulinger SC, Fiedler B, Philippi M, Schütte F, Singh A, Hauss H, Karstensen J, Körtzinger A, Künzel S, Schmitz RA
Hidden biosphere in an oxygen-deficient Atlantic open ocean eddy: future implications of ocean deoxygenation on primary production in the eastern tropical North Atlantic.
Biogeosciences. 12, 7467-7482.

Kalvelage T, Lavik G, Jensen MM, Revsbech NP, Löscher C, Schunck H, Desai DK, Hauss H, Kiko R, Holtappels M, LaRoche J, Schmitz RA, Graco MI, Kuypers MM
Aerobic Microbial Respiration In Oceanic Oxygen Minimum Zones.
PLoS One. 10(7):e0133526.

Midekssa, MJ, Löscher, CR, Schmitz, RA, Assefa F
Characterization of phosphate solubilizing rhizobacteria isolated from lentil growing areas of Ethiopia.
Afr J Microbiol Res. 9:1637-1648.

Weiland-Bräuer N, Neulinger SC, Pinnow N, Künzel S, Baines JF, Schmitz RA
Changing company: Composition of bacterial communities associated with Aurelia aurita changes with compartment, life stage and population.
Appl environ microbiol. 81(17):6038-52.

Arévalo-Martínez DL, Kock A, Löscher CR, Schmitz RA, Bange HW
Massive nitrous oxide emissions from the tropical South Pacific Ocean.
Nature Geoscience.
8: 530–533.

Heinsen FA, Knecht H, Neulinger SC, Schmitz RA, Däumer C, Kühbacher T, Rosenstiel PC, Schreiber S, Friedrichs AK, Ott SJ
Dynamic changes of the luminal and mucosa-associated gut microbiota during and after antibiotic therapy with paromomycin.
Gut microbes,

Prasse D, Thomsen J, DeSantis R, Muntel J, Becher D, Schmitz RA
First description of small proteins encoded by spRNAs in Methanosarcina mazei strain Gö1.
Biochimie, 117:138-48.

Bang C, Schmitz RA
Archaea associated with human surfaces: not to be underestimated.
FEMS Microbiol rev, 39(5):631-48.

Bauersachs T, Weidenbach K, Schmitz RA, Lorenz Schwark L
Distribution of glycerol ether lipids in halophilic, methanogenic and hyperthermophilic archaea.
Organic Geochemistry, 83–84: 101–108.

Löscher CR, LaRoche J, Schmitz RA
Nitrogen fixation.
ed. DeBruin, CHAPTER 105: Underestimation of marine dinitrogen fixation: A novel method and novel diazotrophic habitats. Review. No abstract available.


Weiland-Bräuer N, Pinnow N, Schmitz RA
Novel reporter for identification of interference with AHL and autoinducer-2 quorum sensing..
Appl environ Microbiol. 81(4):1477-89.

Langfeldt D, Neulinger SC, Stiesch M, Stumpp N, Bang C, Schmitz RA, Eberhard J
Health- and disease-associated species clusters in complex natural biofilms determine the innate immune response in oral epithelial cells during biofilm maturation.
FEMS Microbiol Lett. 360(2):137-43.

Bang C, Ehlers C, Orell A, Prasse D, Spinner M, Gorb SN, Albers SV, Schmitz RA
Biofilm formation of mucosa-associated methanoarchaeal strains.
Front Microbiol. 5:353.

Weidenbach K, Ehlers C, Schmitz RA
The transcriptional activator NrpA is crucial for inducing nitrogen fixation in Methanosarcina mazei Gö1 under nitrogen limitation.
FEBS J. 281(15):3507-22.

Bang C, Weidenbach K, Gutsmann T, Heine H, Schmitz RA
The intestinal Archaea Methanosphaera stadtmanae and Methanobrevibacter smithii Activate human dendritic cells.
PLoS One. 9(6):e99411.

Löscher CR, Großkopf T, Desai FD, Gill D, Schunck H, Croot PL, Schlosser C, Neulinger SC, Pinnow N, Lavik G, Kuypers MM, LaRoche J, Schmitz RA
Facets of diazotrophy in the oxygen minimum zone waters off Peru.
ISME J.  8(11):2180-92.

Knecht H, Neulinger SC, Heinsen FA, Knecht C, Schilhabel A, Schmitz RA, Zimmermann A, dos Santos VM, Ferrer M, Rosenstiel PC, Schreiber S, Friedrichs AK, Ott SJ
Effects of β-lactam antibiotics and fluoroquinolones on human gut microbiota in relation to Clostridium difficile associated diarrhea.
PLoS One. 9(2):e89417.

Brendel J, Stoll B, Lange SJ, Sharma K, Lenz C, Stachler A, Maier L, Richter H, Nickel L, Schmitz RA, Randau L, Urlaub H, Backofen R, Marchfelder A
A complex of Cas proteins 5, 6, and 7 is required for the biogenesis and stability of clustered regularly interspaced short palindromic repeats (crispr)-derived rnas (crrnas) in Haloferax volcanii.
JBC. 289: 7164-7177.

Susanti D, Wong JH, Vensel WH, Loganathan U, DeSantis R, Schmitz RA, Balsera M, Buchanan BB, Mukhopadhyay B
Thioredoxin targets fundamental processes in a methane-producing archaeon, Methanocaldococcus jannaschii.
Proc Natl Acad Sci U S A. 111(7): 2608-13.

Langfeldt D, Neulinger SC, Heuer W, Staufenbiel I, Künzel S, Baines JF, Eberhard J, Schmitz RA
Composition of microbial oral biofilms during maturation in young healthy adults.
PLoS One. 9(2): e87449.


Schunck H, Lavik G, Desai DK, Großkopf T, Kalvelage T, Löscher CR, Paulmier A, Contreras S, Siegel H, Holtappels M, Rosenstiel P, Schilhabel MB, Graco M, Schmitz RA, Kuypers MM, Laroche J
Giant hydrogen sulfide plume in the oxygen minimum zone off Peru supports chemolithoautotrophy.
PLoS One. 8(8): e68661.

Kalvelage T, Lavik G, Lam P, Contreras S, Arteaga L, Löscher C, Oschlies A, Paulmier A, Stramma L, Kuypers M
Nitrogen cycling driven by organic matter export in the South Pacific oxygen minimum zone.
Nature Geoscience. 6:228–234.

Nickel L, Weidenbach K, Jäger D, Backofen R, Lange SJ, Heidrich N, Schmitz RA
Two CRISPR-Cas systems in Methanosarcina mazei strain Gö1 display common processing features despite belonging to different types I and III.
RNA Biology. 10(5): 779-91.

Bertics VJ, Löscher C, Salonen I, Schmitz RA, Treude T
Occurrence of benthic microbial nitrogen fixation, coupled to sulfate reduction, and denitrification in the seasonally hypoxic Eckernförde Bay, Baltic Sea.
Biogeosciences. 10: 1243-1258.

Eberhard J , Grote K, Luchtefeld M, Heuer W, Schuett H, Divchev D, Scherer R, Schmitz-Streit R, Langfeldt D, Stumpp N, Staufenbiel I, Schieffer B, Stiesch M
Experimental Gingivitis Induces Systemic Inflammatory Markers in Young Healthy Individuals: A Single-Subject Interventional Study.
PLOS one. 8(2): e55265.

Prasse D, Ehlers C, Backofen R, Schmitz RA
Regulatory RNAs in archaea: first target identification in Methanoarchaea.
Biochem Soc Trans. 41(1): 344-9.

Balsera M, Uberegui E, Dwi S, Schmitz RA, Mukhopadhyay B, Schürmann P, Buchanan BB
Ferredoxin-thioredoxin reductase (FTR) links the regulation of oxygenic photosynthesis to deeply rooted bacteria.
Planta. 237(2): 619-35.


Jäger D, Pernitzsch SR, Richter A, Backofen R, Sharma CM, Schmitz RA
An archaeal sRNA targeting cis- and trans-encoded mRNAs via two distinct domains.
Nucleic Acid Research. 40(21): 10964-79.

Großkopf T, Mohr W, Baustian T, Schunck H, Gill D, Kuypers MM, Lavik G, Schmitz RA, Wallace DWR, LaRoche L
Doubling of marine N2 fixation rates based on direct measurements.
NATURE. 488(7411): 361-4.

Ilmberger N, Meske D, Juergensen J, Schulte M, Barthen P, Rabausch U, Angelov A, Mientus M, Liebl W, Schmitz RA, Streit WR
Metagenomic cellulases highly tolerant towards the presence of ionic liquids - linking thermostability and halotolerance.
Appl microbiol biotechnol. 95(1): 135-46.

Marchfelder A, Fischer S, Brendel J, Stoll B, Maier L-K, Jäger D, Prasse D, Plagens A, Schmitz R A, Randau L
Small RNAs for Defence and Regulation in Archaea.
Extremophiles. 16(5): 685-96.

Löscher C, Kock A, Könneke M, LaRoche J, Bange HW, Schmitz RA
Evidence for oceanic nitrous oxide production by ammonia-oxidizing archaea.
Biogeosciences. 9: 2419-2429.

Bang C, Schilhabel A, Weidenbach K, Kopp A, Goldmann T, Gutsmann T, Schmitz RA
Effects of Antimicrobial Peptides on Methanogenic Archaea.
Antimicrob Agents Chemother. 56(8): 4123-30.


Schmitz RA, Jäger D, Jellen-Ritter A, Babski J, Soppa J, Marchfelder A
Archaea employ small RNA as regulators.
In Regulatory RNAs in Prokaryotes (Hess, W.R. and Marchfelder, A. eds.), Springer, Vienna. No abstract available.

Thomas F, Diaz-Bone R, Würfel O, Huber B, Weidenbach K, Schmitz RA, Hensel R
Connection between multimetal(loid) methylation in methanoarchaea and central intermediates of methanogenesis.
Appl environ Microbiol. 77(24): 8669-8675.

Ehlers C, Jäger D, Schmitz, RA
Establishing a markerless genetic exchange system for Methanosarcina mazei strain Gö1 for constructing chromosomal mutants of small RNA genes
Archaea. 439608. Epub 2011 Sep 20.

Egert M, Schmidt I, Höhne H-M, Lachnit T, Schmitz RA, Breves R
Ribosomal RNA-based profiling of bacteria in the axilla of healthy males suggests right-left asymmetry in bacterial activity
FEMS Microbiology Ecology. 77: 146-53.

Lachnit T, Meske D, Wahl M, Harder T, Schmitz RA.
Epibacterial community patterns on marine macroalgae are host-specific but temporally variable
Environ Microbiol. 13(3): 655-65.

Milenkov M, Thummer R, Glöer J, Grötzinger J, Jung S, Schmitz RA
Insights into membrane association of Klebsiella pneumoniae NifL under N2 - fixing conditions by mutational analysis
J Bacteriology. 193(3): 695-705.


Barz M, Beimgraben C, Staller T, Germer F, Opitz F, Marquardt C, Schwarz C, Gutekunst C, Vanselow KH, Schmitz RA, LaRoche J, Schulz R, Appel J.
Distribution analysis of hydrogenases in surface waters of marine and freshwater environments
PLos ONE. 5(11): e13846.

Weidenbach K, Ehlers C, Kock J, Schmitz RA.
NrpRII mediates contacts between NrpRI and general transcription factors in the archaeon Methanosarcina mazei Gö1
FEBS J. 277: 4398-4411.

Weiland N, Löscher C, Metzger R, Schmitz RA.
Construction and screening marine metagenomic libraries.
Methods Mol Biol. 668: 51-65.


Jäger D, Sharma CM, Thomsen J, Ehlers C, Vogel J, Schmitz RA.
Deep sequencing analysis of the Methanosarcina mazei Gö1 transcriptome in response to nitrogen availability
Proc Natl Acad Sci U S A. 106(51): 21878-82

Schmeisser C, Liesegang H, Krysciak D, Bakkou N, Le Quéré A, Wollherr A, Heinemeyer I, Morgenstern B, Pommerening-Röser A, Flores M, Palacios R, Brenner S, Gottschalk G, Schmitz RA, Broughton WJ, Perret X, Strittmatter AW, Streit WR.
Rhizobium sp. NGR234 possesses a remarkable number of secretion systems
Appl Environ Microbiol. 75(12): 4035-45.


Glöer J, Thummer R, Ullrich H, Schmitz RA.
Towards understanding the nitrogen signal transduction for nif gene expression in Klebsiella pneumoniae
FEBS J. 275(24): 6281-94.

Weidenbach K, Ehlers C, Kock J, Ehrenreich A, Schmitz RA.
Insights into the NrpR regulon in Methanosarcina mazei Gö1
Arch Microbiol. 190(3): 319-32.

Weidenbach K, Glöer J, Ehlers C, Sandman K, Reeve JN, Schmitz RA.
Deletion of the archaeal histone in Methanosarcina mazei Gö1 results in reduced growth and genomic transcription.
Mol Microbiol. 67(3): 662-71.


Urban JH, Papenfort K, Thomsen J, Schmitz RA, Vogel J.
A Conserved Small RNA Promotes Discoordinate Expression of the glmUS Operon mRNA to Activate GlmS Synthesis.
J Mol Biol. 373(3): 521-8.

Thummer R, Klimmek O, Schmitz RA.
Biochemical Studies of Klebsiella pneumoniae NifL Reduction Using Reconstituted Partial Anaerobic Respiratory Chains of Wolinella succinogenes.
J Biol Chem. 282(17): 12517-12526.


Veit K, Ehlers C, Ehrenreich A, Salmon K, Hovey R, Gunsalus RP, Deppenmeier U, Schmitz RA
Global transcriptional analysis of Methanosarcina mazei strain Gö1 under different nitrogen availabilities.
Mol Genet Genomics. 276(1): 41-55.


Reeve JN, Schmitz RA
Biology, biochemistry and the molecular machinery of Archaea.
Curr Opin Microbiol. 8(6): 627-9.

Veit K, Ehlers C, Schmitz RA
Effects of nitrogen and carbon sources on transcription of soluble methyltransferases in Methanosarcina mazei strain Gö1.
J Bacteriology. 187: 6147-6154.

Ehlers C, Weidenbach K, Veit K, Deppenmeier U, Metcalf W, Schmitz RA
Development of genetic methods and construction of chromosomal glnK1 mutant in Methanosarcina mazei strain Gö1.
Mol Genet Genomics. 273: 290-298.

Ehlers C, Weidenbach K, Veit K, Forchhammer K, Schmitz RA
Unique mechanistic features of post translational regulation of glutamin synthetase activity in Methanosarcina mazei in response to nitrogen availability.
Mol Microbiol. 55: 1841-1854.


Streit WR, Schmitz RA
Metagenomics - the key to the uncultured microbes.
Curr Opin Microbiol. 7: 492 - 498.

Stips J, Thummer R, Neumann M, Schmitz RA
GlnK effects complex formation between NifA and NifL in Klebsiella pneumoniae.
Eur J Biochem. 271: 3379-3388.

Schmitz RA, Achebach S, Unden G
Analysis of Fumarate nitrate reductase regulator as oxygen sensor in Escherichia coli. In 'Methods in Enzymology, Volume 381, Oxygen sensing'.
Sen CK & Semenza GL (eds.), Academic press Inc., New York. pp 628. No abstract available.

Streit WR, Schmitz RA, Perret X, Staehelin C, Deakin WJ, Raasch C, Liesegang H, Broughton WJ
An Evolutionary Hot Spot: the pNGR234b Replicon of Rhizobium sp. Strain NGR234.
J Bacteriology.186: 535 - 542.


Schmeisser C, Stöckigt C, Raasch C, Wingender J, Timmis KN, Wenderoth DF, Flemming H-C, Liesegang H, Schmitz RA, Jaeger K-E, Streit WR
Metagenome Survey of Biofilms in Drinking Water Networks.
Appl Environ Microbiol. 69: 7298-7309.

Grabbe R, Schmitz RA.
Oxygen control of nif gene expression in Klebsiella pneumoniae depends on NifL reduction at the cytoplasmic membrane by electrons derived from the reduced quinone pool.
Eur J Biochem. 270(7): 1555-66.


Deppenmeier U, Schmitz RA, Gunsalus RP, Fritz HJ, Gottschalk G.
The genome of Methanosarcina mazei: evidence for lateral gene transfer between bacteria and archaea.
J Mol Microbiol Biotechnol. 4(4): 453-61

Schmitz RA, Klopprogge K, Grabbe R, Stips J
Regulation of nitrogen fixation in Klebsiella pneumoniae and Azotobacter vinelandii: NifL, transducing two environmental signals to the nif transcriptional activator NifA .
In 'Regulatory networks in Prokaryotes' Dürre P & Friedrich B (eds.), p. 65-72, Horizon Scientific press, Norfolk. No abstract available.

Schmitz RA, Klopprogge K, Grabbe R
Regulation of nitrogen fixation in Klebsiella pneumoniae and Azotobacter vinelandii: NifL, transducing two environmental signals to the nif transcriptional activator NifA (Minireview).
J Mol Microbiol. Biotechnol. 4: 235-242.

Klopprogge K, Grabbe R, Hoppert M, Schmitz RA
Membrane association of Klebsiella pneumoniae NifL is affected by molecular oxygen and combined nitrogen.
Arch Microbiol. 117: 223-234.

Klopprogge K, Stips J, Schmitz RA
The inhibitory form of NifL from Klebsiella  pneumoniae exhibits ATPase activity only when synthesized under nitrogen sufficiency.
Biochem Biophys. Acta. 1594: 243-54.

Ehlers C, Grabbe R, Veit K, Schmitz RA
Characterization of GlnK1 from Methanosarcina mazei strain Gö1: Complementation of an Escherichia coli glnK mutant strain by M. mazei GlnK1.
J Bacteriol. 184: 1028-1040.


Grabbe R, Kuhn A, Schmitz RA
Cloning, sequencing and characterization of Fnr from Klebsiella pneumoniae.
Antonie Van Leeuwenhoek. 79(3-4): 319-26.

Grabbe R, Klopprogge K, Schmitz RA.
Fnr Is required for NifL-dependent oxygen control of nif gene expression in Klebsiella pneumoniae.
J Bacteriol. 183(4): 1385-93.


Henne A, Schmitz RA, Bömeke M, Gottschalk G, Daniel R
Screening of environmental DNA libraries for the presence of genes conferring lipolytic activity on Escherichia coli.
Appl Environ Microbiol. 66: 3113-3116.


Henne A, Daniel R, Schmitz RA, Gottschalk, G
Construction of environmental DNA libraries in Escherichia coli and screening for the presence of genes conferring utilization of 4-hydroxybutyrate.
Appl Environ Microbiol. 65: 3901-3907.

Articles in German

Daniel R, Schmitz RA, Streit W (2002) aus Wattenmeer und Wüstensand.
Georgia Augusta. 1: 111-115.

additional Publications in PubMed