Analysing the M. mazei immune system 

The second classes of regulatory RNAs we are studying are so called crRNAs, which are part of the Prokaryotic immune system - the CRISPR/Cas system - in M. mazei. The CRISPR (clustered regularly interspaced short palindromic repeats) system has been only recently discovered as defense system against exogenous nucleic acids in bacteria and archaea. In contrast to other gene transfer and phage defense mechanisms it allows a highly adaptive and heritable resistance mechanism that incorporates sequences derived from foreign elements into the respective CRISPR locus. Thus, the CRISPR system represents an adaptive immune system of the Prokaryotes. We are aiming to unravel the function of several Cas proteins and complexes in M. mazei, and achieve an insight regarding crRNA processing and potentially on methanoarchaea / phage dynamics. (funded by DFG, FOR1680)

Analysing the M. mazei immune system

Enriched methanoarchael phages

Enriched methanoarchael phages