Comparative analyses of novel glycolytic pathways (glucose) of extremophilic archaea

Hyperthermophilic archaea degrade glucose via modified Embden-Meyerhof (EM) pathways, which differ from the classical EM pathway by several novel enzymes and catalytic reactions, and unusual energetics (ATP yields). Since the hyperthermophilic bacterium Thermotoga utilizes the classical EM pathway, it is concluded that the modifications in archaeal glycolysis are a result of a domain specific evolution rather than an adaptation to a hyperthermophilic life style.
Enzymes of the classical EM pathway are shown in red, modified enzymes of archaeal glycolysis are marked by different colors
Enzymes of the classical EM pathway are shown in red, modified enzymes of archaeal glycolysis are marked by different colors.