The innate immune system encountering methanogenic archaea

Archaea the second domain of Prokarya are phylogenetically distant to Bacteria and Eukarya, which is expressed in genetic differences as well as structural differences of the cell wall. Though methanogenic archaea form part of the indigenous microflora of the human gut, until today it is not clear whether antimicrobial peptides (AMPs) affect them as the archaeal cell envelope differs profoundly in terms of chemical composition and structure from that of bacteria. In this project we are addressing if and how antimicrobial peptides act against (methano)archaea and study the response of the innate immune system encountering Methanosphaera stadtmanae andMethanobrevibacter smithii, both considered to be inhabitants of the human gut, and M. mazei. (funded by the DFG)

M. smithii